Acute Exposure Guideline Levels for Selected Airborne by National Research Council, Division on Earth and Life

By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

Document from the Subcommittee on Acute publicity guide degrees and the Committee on Toxicology from the Board on Environmental stories and Toxicology. quantity 2. Softcover.

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Extra info for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2

Example text

He was treated with oxygen, bronchodilators, steroids, and antibiotics and returned to work 6 d after the accident. His follow-up was unremarkable. The second man, a 47-y-old smoker, presented with dyspnea, bilateral rales, and pulmonary edema 11 h postexposure. He was also treated with oxygen, bronchodialators, steroids, and antibiotics but continued to deteriorate. He remained critical for 3 d with low right-side heart pressure, low arterial pressure, hemoconcentration, and leukocytosis. He was asymptomatic by 12 d postexposure.

5, or 1 ppm for 4 h and sacrificed on day 0, 1, 2, or 3 postexposure (Currie et al. 1987a). 32 m3 Rochester-type inhalation chambers. 32 m3/min, and the gas mixture passed downward through stainless steel wire cages holding the animals and was exhausted at the bottom through a water scrubber. 4°C, and humidity was 60±10% during exposures. The chambers were monitored by both infrared analysis and gas chromatography continuously during exposure, and even phosgene distribution was assured by sampling from various areas of the exposure chamber.

1. Mouse Zwart et al. (1990) exposed groups of five male and five female Swiss mice to phosgene at varying concentrations for 5, 10, 30, or 60 min. The test atmosphere was monitored at both the inlet and outlet of the glass exposure chambers by gas chromatography and infrared analysis. Ten-minute LC50 values were 77 and 61 ppm for males and females, respectively. Thirty-minute LC50 values were 18 and 11 ppm for males and females, respectively, and 60-min LC50 values were determined to be 9 and 5 ppm for males and females, respectively.

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