Age-related Macular Degeneration by L. Ho, R. van Leeuwen, P. T. V. M. de Jong, J. R.

By L. Ho, R. van Leeuwen, P. T. V. M. de Jong, J. R. Vingerling, C. C. W. Klaver (auth.), Frank G. Holz, Daniel Pauleikhoff, Richard F. Spaide, Alan C. Bird (eds.)

Age-related macular degeneration is the commonest reason for the lack of imperative imaginative and prescient past the age of fifty in business international locations. Triplication of the variety of affected sufferers is predicted over the following 25 years. in particular over the past years the normal of information relating to etiology, chance components, diagnostics and treatment of this retina sickness has considerably grown – this may be coated during this updated multi-authored paintings. except epidemiologically and genetically pointed out danger elements either a few of the pathophysiological features together with the position of the supplement process and scientific manifestations together with OCT and angiographic features are essentially represented. in addition, the several healing techniques are awarded and mentioned, together with confirmed approaches comparable to intravitreal anti-VEGF remedy and seeing-aid platforms, as well as the most recent and upcoming equipment within the region of pharmacology. the amount is well-illustrated and tables and summaries whole the presentation.

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35. 36. 37. 38. 39. 40. maculopathy: follow-up at 6 1/2 years in the Rotterdam study. Arch Ophthalmol 121(4):519–526 Klein R, Klein BE, Tomany SC, Meuer SM, Huang GH (2002) Ten-year incidence and progression of age-related maculopathy: the Beaver Dam eye study. Ophthalmology 109(10):1767–1779 Mitchell P, Wang JJ, Foran S, Smith W (2002) Five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye Study. Ophthalmology 109(6): 1092–1097 Klaver CC, Assink JJ, van Leeuwen R et al (2001) Incidence and progression rates of age-related maculopathy: the Rotterdam Study.

Fritsche et al. Wang et al. Losonczy et al. Marioli et al. , Chinese C-C Richardson et al. , Utah C-C Hadley et al. 5 1 2 5 b Study or Subgroup Losonczy et al. Marioli et al. Rivera et al. 00001) Favours experimental Favours control Fig. 8 Allele-based meta-analysis association studies investigating LOC387715 A69S and risk of (a) late AMD and (b) early AMD, age-related macular degeneration; CI, confidence interval; IV, inverse variance; n, number of risk alleles; N, total number of alleles; Random, random effects model ORs and 95% CIs were calculated using the random effects model of the DerSimoninian and Laird method non-significant but increased risk of AMD [180, 183– 185, 188, 191, 193, 195, 196].

Chinese C-C Richardson et al. , Utah C-C Hadley et al. 5 1 2 5 b Study or Subgroup Losonczy et al. Marioli et al. Rivera et al. 00001) Favours experimental Favours control Fig. 8 Allele-based meta-analysis association studies investigating LOC387715 A69S and risk of (a) late AMD and (b) early AMD, age-related macular degeneration; CI, confidence interval; IV, inverse variance; n, number of risk alleles; N, total number of alleles; Random, random effects model ORs and 95% CIs were calculated using the random effects model of the DerSimoninian and Laird method non-significant but increased risk of AMD [180, 183– 185, 188, 191, 193, 195, 196].

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