AMP-activated Protein Kinase by Mario D. Cordero, Benoit Viollet

By Mario D. Cordero, Benoit Viollet

AMPK has emerged as a huge integrator of signs that regulate power stability in the course of the rules of a number of biochemical pathways in eukaryotes.

This booklet specializes in the consequences of AMPK as a grasp metabolic regulator in illnesses, together with new equipment and animal types. The contributions are written via prime specialists within the box and provides an in depth evaluate of the present wisdom of AMPK biology and the function of AMPK in wellbeing and fitness and sickness.

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Paradoxically, increased workload in a model of ex vivo perfused working heart increases glucose utilization without any modification in AMP/ATP ratio and AMPK activity but is associated with Akt signaling and increased glycolysis (Beauloye et al. 2002). However, exercise increases cardiac AMPK activity and glucose uptake (Coven et al. 2003), but this could be linked to a β-adrenergic response (An et al. 2005). In the heart, AMPK- 2 Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein.

References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 25 26 28 29 29 30 30 30 31 33 34 34 37 Abstract This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein turnover, mitochondrial biogenesis, and whole-body energy homeostasis.

PFK1 is allosterically activated by increased energy deficit (AMP levels), as well as by fructose-2,6bisphosphate (Fru-2,6-P2) which is synthesized by 6-phosphofructokinase-2 (PFK2). PFK-2 is activated upon phosphorylation by AMPK and promotes glycolysis in the ischemic heart (Marsin et al. 2000), in the activated monocytes (Marsin et al. 2002), and in hypoxic cancer cells (Bando et al. 2005). 3 Glycogen Metabolism Glycogen levels are dynamically regulated as a function of both glycogenesis (glycogen production) and glycogenolysis (glycogen breakdown) in tissues like liver and muscle.

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