BHLH transcription factors in development and disease by Reshma Taneja

By Reshma Taneja

This new quantity of Current issues in Developmental Biology presents a complete set of reports on bHLH transcription factors.  bHLH components are drastically well-known for his or her assorted roles in developmental procedures and their disorder underlies quite a few human pathologies.  every one bankruptcy is authoritatively written through a number one professional within the box and discusses each attainable element of this large and numerous field.

  • Covers the world of simple helix-loop-helix (bHLH) transcription elements in improvement and disease
  • International board of authors
  • Provides a accomplished set of stories on our present knowing at the functionality of bHLH components in improvement of assorted tissues and the way de-regulation of those elements may cause, or is associated with, a variety of human diseases

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Therefore, the evaluation of these parameters for myogenic differentiation of human ES or iPS cells will allow the expansion of more homogenous self-renewable populations of upstream myogenic stem/progenitors enabling future cell-based therapies for muscle-wasting diseases. Molecular and Cellular Regulation 33 5. 1. , 1994). , 1997; Di Padova, Caretti, Zhao, Hoffman, & Sartorelli, 2007). , 2002). , 2007; see Tapscott, 2005). , 2010). This notion was also extended to a human cell culture model of rhabdomyosarcomas, a pediatric tumor of skeletal muscle that resembles undifferentiated myogenic cells (Merlino & Helman, 1999).

2009) will make patient-specific iPS cells a feasible therapeutic approach for myogenic diseases. Nevertheless, a few concerns remain. For all reprogramming strategies, it is important to clearly identify the cell type generated using gene expression signatures, cellular organization of structural proteins, morphology, epigenetic marks, and functional attributes (Addis & Epstein, 2013). In the studies mentioned above, the molecular signature of ES/iPS-derived myogenic cells was not clearly investigated.

2009) will make patient-specific iPS cells a feasible therapeutic approach for myogenic diseases. Nevertheless, a few concerns remain. For all reprogramming strategies, it is important to clearly identify the cell type generated using gene expression signatures, cellular organization of structural proteins, morphology, epigenetic marks, and functional attributes (Addis & Epstein, 2013). In the studies mentioned above, the molecular signature of ES/iPS-derived myogenic cells was not clearly investigated.

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