Basic Nephrology and Acute Kidney Injury by M. Sahay

By M. Sahay

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Extra resources for Basic Nephrology and Acute Kidney Injury

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1 Physiological and analytical data Iohexol is a non-ionic contrast product, mainly used for myelography. , 2006). Iohexol is chronologically the last marker proposed for measuring GFR. , 1980). In this study, it was shown that the substance was safe and fully excreted by the kidneys (this assertion will be criticized thereafter, see below). , 1980). , 1983). , 1983). , 1996). Binding to protein seems very limited for iohexol. , 1980). , 1984). , 1984). , 1984). , 1988b). , 1995). These last very low results were also found by Nossen in 16 patients with severe CKD.

These limitations are confirmed by most of the clinical studies showing that iothalamate slightly overestimates inulin clearance, especially in the high levels of GFR. A clinical limitation concerns the patients who are allergic to contrast product. This marker remains however 40 Basic Nephrology and Acute Kidney Injury important because it is the most used marker in USA. , 1999). 8. 1 Physiological and analytical data Iohexol is a non-ionic contrast product, mainly used for myelography. , 2006).

Comparison of Reference Methods Pierre Delanaye University of Liège, CHU Sart Tilman, Liège Belgium 1. , 1997; Stevens & Levey, 2009). , 2011a; Delanaye & Cohen, 2008; Stevens & Levey, 2009). In this chapter, we will review the different markers which can be considered as reference methods to measure GFR. Before moving to clinical trials, we have to recall the physiological characteristics of an ideal GFR marker. 2. Clearance concept and ideal marker for glomerular filtration rate The history of the renal physiology is deeply influenced by the book published by Homer W.

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