Biological Characterization of Bone Tumors by G. C. Steiner (auth.), A. Roessner (eds.)

By G. C. Steiner (auth.), A. Roessner (eds.)

During the earlier few years, plenty of monographs on bone tumors were released. they're usually limited to bone tumors as clinical-pathological entities, on account that their analysis, greater than that of alternative tumors, calls for the interdisciplinary cooperation among orthopedic professional, radiologist, and pathologist. even if, investiga­ tions about the histogenesis of bone tumors are quite restricted, even though they may be worthwhile in explaining the original morphological heterogeneity of tumors of the skeletal approach. moreover, the histo­ genetic method within the research of bone tumors may possibly facilitate the inter­ pretation of the complex cytobiological equipment to be had for improv­ ing type and prognosis. as a result, this quantity offers contemporary pathological advances within the organic characterization of bone tumors. an enormous bankruptcy offers with the differential analysis of Ewing's sarcoma as regards its demarcation from the so-called neuroectodermal tumor of bone. The research of the floor ingredients in bone-forming tumors should be beneficial for his or her type. for that reason the quantity incorporates a bankruptcy at the biochemical and histochemical research of alternative osteosarcoma forms. lately it has develop into transparent that during addition to diverse collagen kinds which aren't particular for bone tissue, numerous bone-specific proteins happen, considered one of that's osteonectin. Its distribu­ tion is clearly vital for the type and prognosis of osteo­ blastic tumors. Proliferative habit is of significant value for the analysis of malignant tumors.

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6 Soft Tissue Tumors . . . . 4 Discussion........... 1 Osteonectin as a Constituent of Bone Matrix Proteins . 2 Functional Aspects of Osteonectin . . . . 3 Osteonectin as a Marker Protein of Osteoblasts . 4 Osteonectin Antibodies in Bone-Forming Tumors. Summary. 5 References. . . . . . . . . . 31 32 32 32 33 33 33 34 34 36 36 36 36 38 38 38 42 42 45 45 45 45 50 51 51 52 53 1 Introduction The principal protein component of bone matrix is type-I collagen. Although it is the only type of collagen present it is not bone specific because it is also found in nonmineralizing connective tissue of the skin, lung, liver, eyes, and tendons (CHURCH 1981; GAY and RHODES 1980; VON DER MARK 1981).

B Distinct cytoplasmic staining of spindle-shaped tumor cells ( x 300). Antiosteonectin, ABC, no counterstaining, Nomarski Immunohistological Demonstration of Osteonectin in Normal Bone Tissue 49 **Proteoglycans I and II ** __ Bone Sialoprotein (Osteopontin) and - Bone Sialoprotein II Other noncollagenous proteins -Osteonectin , I Albumin "0<2- HS Glycoprotein Fig. 12. Distribution of NCPs in developing bone (according to TERMINE 1987) the form of hydroxyapatite, thus forming the mineralized bone.

Histological and Biochemical Analyses of Osteosarcomas Morphological and Histological Description of Large Tumor Samples . Biochemical Data . . . . . . . . . Zonal Combined Biochemical and Histological Analyses. Zonal Morphological and Histological Characterization . Zonal Biochemical Characterization . . . . . Comparison of Hard Tissue Formation in Osteosarcomas with Physiological Bone Formation . References. . . . . . . . . . . . . . . . . . . 55 56 56 58 61 66 66 67 67 70 77 77 79 84 88 1 Introduction Generally osteosarcomas show a pattern of considerable heterogeneity.

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