Biological Modulation of Solid Tumours by Interferons by K. Pummer (auth.), Karl Pummer M.D. (eds.)

By K. Pummer (auth.), Karl Pummer M.D. (eds.)

In the Nineteen Sixties, it used to be pronounced that interferons have antitumour job in numerous experimental types. on account that that point, a number of reviews were played to clarify many of the mechanisms of motion which have been proposed. although, there's a lot controversy within the literature and promising preclinical findings didn't translate into monstrous medical growth. the current publication provides a serious assessment of present wisdom of the way interferons act in strong tumours. For this function, after chapters of normal facets of interferon motion and interplay, chosen sturdy tumours that are as a rule thought of tricky to regard in complicated phases are mentioned with recognize to either preclinical info and medical experience.

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J Clin Oncol 1989 (7):1769-1775 pazdur R, Ajani JA, Patt YZ, et al: Phase II study of fluorouracil and recombinant interferon alfa-2a in previously untreated advanced colorectal carcinoma. J Clin Oncol1990 (8):2027-2031 Gresser I, Bourali C, Levy JP, Brouty-Boye 0, Thomas MT: Increased survival in mice inoculated with tumor cells and treated with interferon preparations. Proc Natl Acad Sci USA 1969 (63):5157 Gresser I, Bouraly C: Antitumor effects of interferon preparations in mice. JNCI 1970 (45):365-376 Nishiyama M, Takagami S, Kirihara Y, et al: Combined effects of interferon alpha-AID with fluoropyrimidine derivates in the subrenal capsule a~say.

Locally injected NK cells became activated in situ, and they produced various cytokines subsequently. In particular IFN-y appeared to contribute to the observed growth inhibitory effect as determined by the application of neutralising antibodies. Finally, peritumoural injection of IFN-y alone caused significant growth inhibition of squamous cell head and neck carcinoma xenografts. Differentiation Cellular proliferation and differentiation appear to be regulated by discrete gene products in- Head and Neck Cancer cluding hormone-like effector proteins such as interferons [23].

The role of host immune response in the antitumour activity of IFNs has been confirmed by other studies [41]. Two sublines of melanoma B16, one resistant and the other sensitive to the direct antiproliferative effect of I FN-a in vitro when inoculated in mice, responded in the same way to IFN treatment, thus suggesting that IFN may exert its antitumour activityin vivo through the host defense system. The mechanisms by which IFNs mediate antitumour activity in vivo may be different according to the type of IFN used.

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